Sudden cardiac death in the young: A consensus statement on recommended practices for cardiac examination by pathologists from the Society for Cardiovascular Pathology.

Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated. Across the United States, SCD cases in those less than 40 years of age will often fall under medical examiner/coroner jurisdiction resulting in scene investigation, review of available medical records and a complete autopsy including toxicological and histological studies. To date, there have not been consistent or uniform guidelines for cardiac examination in these cases. In addition, many medical examiner/coroner offices are understaffed and/or underfunded, both of which may hamper specialized examinations or studies (e.g., molecular testing). Use of such guidelines by pathologists in cases of SCD in decedents aged 1-39 years of age could result in life-saving medical intervention for other family members. These recommendations also may provide support for underfunded offices to argue for the significance of this specialized testing. As cardiac examinations in the setting of SCD in the young fall under ME/C jurisdiction, this consensus paper has been developed with members of the Society of Cardiovascular Pathology working with cardiovascular pathology-trained, practicing forensic pathologists.

A comparative autopsy study of the injury distribution and severity between suicidal and accidental high falls.

Falls are the second cause of accidental deaths worldwide. Falls from height are also a common method of suicide. The aim of this study is to compare the characteristics of the victims, the circumstances of the fall and the severity and distribution of the injuries reported in an autopsy case series of falls from height. This study is a retrospective analysis of consecutive autopsy cases of suicidal and accidental falls from height which were investigated in the Department of Forensic Medicine and Toxicology of the National and Kapodistrian University of Athens during the period 2011-2019. The recorded variables included demographic data of the victim, height of fall, length of hospital stay, toxicological results, the existence and location of injuries and Injury Severity Score (ISS). Victims of suicidal falls were younger (55.53 vs. 62.98, p = 0.001), they fell from higher heights (12.35 vs. 5.18 m, p < 0.001), and they sustained more severe injuries compared with victims of accidental falls (ISS 51.01 vs. 40.88, p < 0.001). Injuries in the thorax, abdomen, pelvis, upper and lower extremities were more frequently observed after a suicidal fall (93.6% vs. 67.3%, 72.1% vs. 21.4%, 72.1% vs. 27.6%, 42.9% vs. 15.3%, 45.7% vs. 13.3%, respectively-p < 0.001), probably due to the higher height of fall. Our study outlines the differences in the profile of the victims and in the severity of injuries caused by falls from height depending on the intention of the victim to fall. However, a distinctive injury pattern in victims of suicidal falls was not demonstrated.

Regional delamination strength in the human aorta underlies the anatomical localization of the dissection channel.

Aortic dissection is a life-threatening event, during which a primary tear propagates along the aorta causing catastrophic delamination of the inner (intima with most of the media) from the outer layers (leftover media with adventitia). Our understanding of mode-I fracture resistance at different aortic regions is incomplete, although the anatomical localization of the dissection channel may be assigned to this factor. To determine whether the susceptibility to dissection propagation varied with aortic region, the average and standard deviation of peel tension (indices of adhesive strength between layers when pulled apart and its fluctuation) were measured in 24 cadaveric subjects. Measurements were made in the inner and outer quadrants of 9 consecutive regions. Strong regional heterogeneity was established that was age-related based on the following evidence: (1) the average and standard deviation of peel tension peaked in the ascending aorta, decreasing to almost constant values in the descending thoracic aorta, but increasing across the abdominal aorta; (2) axial differences were more pronounced in the inner quadrant, with differences among quadrants reaching significance proximally; (3) the average peel tension was greatly impaired from <40 to 40-60 but much less to >60-year-old subjects at most regions/quadrants, leading to non-uniform axial variations in all age groups; (4) gender affected little the data. This comprehensive series of delamination tests explains the clinical observation of most dissections initiating in the ascending aorta to extend distally and of few dissections initiating in the descending thoracic aorta to extend proximally, while supporting the increased vulnerability in aged subjects.

Subdural and epidural hematoma occurrence in relation to the head impact site: An autopsy study.

Blunt head injury is a major public health and socioeconomic problem causing death and disability particularly among the young population throughout the world. The purpose of the present study was to evaluate if the impact site is correlated with the subdural and epidural hematoma occurrence. A retrospective analysis of consecutive autopsy cases submitted to our Department during a 5-year period was performed. The basic criterion for inclusion in the study was death due to blunt head injury. The recorded variables included the circumstances of death, the existence, and location of head injuries, the primary impact site, age, gender, and toxicological results. A total number of 683 fatal head injury cases was recorded, with most of them being male (74.1%). In 424 cases (62.1%) fatal head injuries were due to road traffic accidents. Fall (from height or on the ground) was the cause of death in 220 (32.2%) cases followed by inflicted impact-assault in 26 (3.8%) cases. A subdural hematoma was found more frequently (26.9%) than epidural (5.0%). Epidural hematomas were found only under the primary impact site, whereas subdural hematomas were coup, contrecoup, or bilateral. An epidural hematoma was found to be almost 5 times more frequent in cases in which a subdural hematoma was present. A higher proportion of subdural, as well as epidural hematoma, was found when the site of impact was the temporal region, followed by the parietal one. Sex did not exert any influence on the probability of subdural and epidural hematoma, whereas for age, a 10% increase in the probability of subdural hematoma occurrence was observed with 10-year age increase.

Layer-Specific Residual Deformations and Their Variation Along the Human Aorta.

This study described the regional distribution of layer-specific residual deformations in fifteen human aortas collected during autopsy. Circumferentially and axially cut strips of standardized dimensions from the anterior quadrant of nine consecutive aortic levels were photographed to obtain the zero-stress state for the intact wall. The strips were then dissected into layers that were also photographed to obtain their zero-stress state. Changes in layer-specific opening angle, residual stretches, and thickness at each aortic level and direction were determined via image analysis. The circumferential and axial opening angles of the intima were ∼240 deg and ∼30 deg, respectively, throughout the aorta; those of the adventitia were ∼150 deg and -20 deg to 70 deg. The opening angles of the intact wall and media were similar in either direction. The circumferential residual stretches of the intima and the axial residual stretches of the media showed high values in the aortic arch, decreasing in the descending thoracic aorta and increasing toward the iliac artery bifurcation, while the axial residual stretches of the adventitia increased distally. The remaining residual stretches did not vary significantly with aortic level, suggesting an intimal role in determining circumferential, as well as medial and adventitial roles in determining axial residual stretches. We conclude that the tensile residual stretches released in the intima and media upon separation, and the compressive residual stretches released in the adventitia may moderate the inverse transmural stress gradients under physiologic loads, resulting from the >180 deg circumferential opening angle of the intact wall.

Self-immolation Suicide in Greece: A Forensic Psychiatric Autopsy Study between 2011 and 2019.

Self-immolation is a rare suicide method in the developed countries of the western world (0.06-1%); however, it has relatively higher prevalence rates in the developing countries of Asia and Africa (6-57%). The present study aims to examine self-immolation suicides within the Greek mainland (Attiki, Thrace, and Peloponnese) over a period of 9 years (2011-2019) in order to investigate the phenomenon in the Greek population forensically, identify the characteristics and motivations of suicide victims, explore its associations to socio-cultural or psychiatric factors, and describe a fatal case of suicide by self-immolation that was partially recorded on camera. The medical files (autopsy reports) of cases performed at the Departments of Forensic Medicine of the National and Kapodistrian University of Athens, Democritus University of Thrace, and the Forensic Service of Messinia-Peloponnese were retrospectively examined yielding 19 cases of suicides by self-immolation. A 3.7% prevalence of suicide by self-immolation among suicide fatalities within the Greek population was estimated. A distinctive feature of the Greek population regarding self-immolation was disclosed that it is being practiced predominantly by the elderly (mean age 2-3.5 decades higher than other countries). The phenomenon correlated strongly with poorly controlled mental disorders (mostly affective and adjustment disorders). Unlike other countries, there was no significant association with domestic or sexual violence, social or political protest, or religious issues. Therefore, the suicide victims preferred secluded or private outdoor locations (not public). Findings deriving from the examined variables localize Greek population culturally between the Western European and Asian African countries, but with its own idiosyncrasies.

Variation of Axial Residual Strains Along the Course and Circumference of Human Aorta Considering Age and Gender.

Our understanding of aortic biomechanics is customarily limited by lack of information on the axial residual stretches of the vessel in both humans and experimental animals that would facilitate the identification of its actual zero-stress state. The aim of this study was thus to acquire hitherto unreported quantitative knowledge of axial opening angle and residual stretches in different segments and quadrants of the human aorta according to age and gender. Twenty-three aortas were harvested during autopsy from the aortic root to the iliac bifurcation and were divided into ≥12 segments and 4 quadrants. Morphometric measurements were taken in the excised/curled configuration of rectangular strips considered to be under zero-stress using image-analysis software to study the axial/circumferential variation of axial opening angle, internal/external residual stretch, and thickness of the aortic wall. The measured data demonstrated: (1) an axial opening angle peak at the arch branches, decreasing toward the ascending and to a near-constant value in the descending thoracic aorta, and increasing in the abdominal aorta; (2) the variation of residual stretches resembled that of opening angle, but axial differences in external residual stretch were more prominent; (3) wall thickness showed a progressive diminution along the vessel; (4) the highest opening angle/residual stretches were found in the inner quadrant and the lowest in the outer quadrant; (5) the anterior was the thinnest quadrant throughout the aorta; (6) age caused thickening but greatly reduced axial opening angle/residual stretches, without differences between males and females.

Incidence of fatalities of road traffic accidents associated with alcohol consumption and the use of psychoactive drugs: A 7-year survey (2011-2017).

Driving under the influence of alcohol and/or psychoactive substances increases the risk of severe, even fatal motor vehicle accidents. The aim of this descriptive study was to present the impact of alcohol and/or psychoactive substances on fatal road traffic accidents (RTAs) during the period 2011-2017. For this purpose, the toxicological investigation reports from the Department of Forensic Medicine and Toxicology of the University of Athens were used. In total, 1,841 (32.2%) of the autopsies conducted by the Department of Forensic Medicine and Toxicology of the National and Kapodistrian University of Athens over a 7-year period (2011-2017) were victims of fatal RTAs. Blood and urine samples were collected and analyzed for the presence of alcohol and psychoactive substances. The results were classified according to sex, age, victim (car driver, motorcyclist, pedestrian, or passenger) and the date the accident occurred (day, month and year). In total, 40.7% of the RTA-related fatalities were associated with alcohol consumption, among which 20.3% were car drivers. Of these, 87.3% were male victims. A higher frequency of RTA-related fatalities associated with a blood alcohol concentration (BAC) >110 mg/dl was encountered in younger compared with older age groups. Psychoactive substances were detected in 348 (18.9%) of the victims (cannabis in 46.6% of these, benzodiazepines in 25.9%, opiates in 16.4% and cocaine in 11.1% of these). The percentage of the RTA-related victims that had consumed alcohol in combination with other psychoactive substances was 4.5%. On the whole, the findings of this study suggest that alcohol and psychoactive substances are probably risk factors for RTA-related fatalities.

Effect of Aneurysm and Bicuspid Aortic Valve on Layer-Specific Ascending Aorta Mechanics.

BACKGROUND: Previous studies have not examined the participation of intimal, medial, and adventitial layers in providing mechanical strength to the ascending thoracic aortic aneurysm (ATAA) wall compared with the nonaneurysmal aorta. In this study we compared the mechanical properties of intact wall and its layers among ATAAs and nonaneurysmal aortas, with explicit consideration of the effects of valve morphology; that is, bicuspid aortic valve (BAV) versus tricuspid aortic valve (TAV), and aortic quadrant. METHODS: Whole ATAAs were taken from patients undergoing elective repair and nonaneurysmal aortas from age-matched autopsy subjects. These were cut into 2 circumferential and longitudinal tissue strips for the intact wall and its layers per quadrant, permitting examination of the aortic wall as a multilayered structure. Tissue underwent tensile testing for determination of failure properties. RESULTS: Intact wall and layer-specific failure stretches (ie, extensibilities) were significantly greater in nonaneurysmal and BAV-ATAA than in TAV-ATAA, unaccounted for by elastin/collagen content changes. Intact wall failure stress (ie, strength) was significantly greater in BAV-ATAA than in TAV-ATAA, in analogy with medial failure stress. Failure stress and stretch associated negatively with age in most subject groups, layers, and intact wall, but failure stretch correlated positively with residual stretch (ie, structural bonds between layers). CONCLUSIONS: No mechanical vulnerability of BAV-ATAA was found, corroborating current conservative guidelines regarding the management of bicuspid aortopathy. Weakening and added vulnerability was found in patients with valvular deficiency, aortic root aneurysm, hypertension, and hyperlipidemia. Aging led to increased susceptibility to dissection initiation or full rupture, or both, in both patient classes.

Regional and age-dependent residual strains, curvature, and dimensions of the human ureter.

The ureters are retroperitoneal structures controlling urine transport from the kidneys to the bladder. Because of the relative scarcity of data on the biomechanical properties of human ureter and the established importance of knowing these properties for understanding its physiology, we initiated biomechanical studies in cadaveric tissue. Herein, we report definite zero-stress/no-load geometrical characterization at 15 regions along the ureter of human cadavers aged 23-82 years, estimating the opening angle, circumferential residual strains, axial curvature, and dimensional parameters. Opening angle decreased along the proximal 25% of ureter, increased and reached a maximum near the mid-ureter, and then gradually decreased toward the vesicoureteral junction (young: p < 0.05; middle-aged: p < 0.05; old: p > 0.05; males: p < 0.05; females: p < 0.05). Similar were the regional distributions of residual strain at the interface between epithelium-lamina propria and muscle and of internal but not external residual strain. Wall thickness increased steadily with aging ( p < 0.05 at few regions), while ureteral circumference did not ( p > 0.05 at most regions) and opening angle decreased ( p < 0.05 at several regions). Consistent with Fung's stress-growth law, the muscle layer thickened with age unlike the epithelium-lamina propria that thinned ( p < 0.05 at most regions for both thicknesses). Moderate-to-strong direct correlations of residual strain difference (= external - internal) with opening angle, wall thickness, and curvature were found in most ureters. The presented data will provide insight into the biomechanical response of ureter under zero/low-stress conditions and the relationship between ureteral remodeling and aging. Importantly, they may also be used to inform finite element models and computational studies simulating the ureter.

Regional distribution of circumferential residual strains in the human aorta according to age and gender.

The biomechanical response of the human aorta varies with axial location, but little is known about the respective variation of residual strains. Such data are available for common lab animals, but in the traditional opening angle measurement the aorta is considered as an ideal cylinder and average residual strains are measured, so that the spatial variations of local residual strains are not determined. The present study provides opening angle and residual strain data throughout the course and around the circumference of the aorta harvested during autopsy. Opening angle showed notable topographical variation; the highest value was at the top of aortic arch, declining abruptly toward the ascending aorta and to a near-constant value in the descending aorta, and rising in the abdominal aorta. The variation of curvature and of external but not internal residual stretch resembled that of opening angle. Extensive residual stress and wall thickness differences were evidenced among quadrants, with the more pre-stressed being also the thicker quadrants. Gender had overall minor effects, but aging led to increased parameters, occurring earlier in the distal aorta but at later stages becoming predominant proximally. Differences in caliber were pronounced in older subjects, unlike those in opening angle, residual stretches, and thickness that were striking in middle-aged subjects. By contrast, curvature decreased with aging in relation to the smaller percentwise opening angle differences. Detailed knowledge of the zero-stress/no-load geometry of the human aortic wall is critical for an in-depth understanding of aortic physiology, while providing the basis for comparison with disease.

Age- and region-related changes in the biomechanical properties and composition of the human ureter.

The ureter has been largely overlooked heretofore in the study of the biomechanics of soft biological tissues, although there has been significant motivation to use its biomechanical properties as inputs to mathematical models of ureteral function. Herein, we used histological analysis for quantification of collagen contents and thickness/area of ureteral layers, with concomitant geometrical analysis of zero-stress and no-load states, and inflation/extension testing to biomechanically characterize with the Fung-type model the ureters from cadavers. The effects of age and gender on the regional distribution of those properties were examined. Tissue properties did not differ (p>0.05) between the left and right ureter. Regional heterogeneity was established that was profoundly age-related but seldom gender-related, based on the following evidence: 1) In younger subjects, the axial stress-circumferential strain curves of upper ureter were shifted to smaller stresses and model parameter a2 representing axial stiffness was smallest (p<0.05), i.e. upper ureter was the least stiff region axially; 2) upper ureter underwent axial stiffening with advanced age, evidenced by the increasing (p<0.05) parameter a2, and the stress-strain curves were uniformly exhibited along the ureter, evidenced by the non-varying (p>0.05) parameters C,a1,a2,anda4; 3) aging raised (p<0.05) the collagen content of upper ureter to favor a near-uniform regional distribution; 4) wall thickness increased with age, unlike the opening angle and residual strains, reflecting the thickening of outer (muscular) vs. inner (mucosal) layers in aged subjects, with significant differences (p<0.05) in some regions; and 5) gender affected little (p>0.05) the opening angle and morphometry of no-load and zero-stress states.

Effects of aneurysm on the mechanical properties and histologic structure of aortic sinuses.

BACKGROUND: Aortic root aneurysms are relatively uncommon but their rupture is a detrimental event with acute hemodynamic compromise and high mortality, and there are few available data on their mechanical properties, although aneurysm rupture occurs when hemodynamic stresses exceed wall strength. This study aimed to fill this gap by examining the effect of aneurysm on the mechanical and structural properties of aortic sinuses. METHODS: Sinus tissue was procured from 16 aneurysmal patients during surgical repair and from 18 age-matched nonaneurysmal autopsy subjects, and grouped by age (young versus old), region (left versus right versus noncoronary), and direction (circumferential versus longitudinal). The tissue was submitted to histologic evaluation of elastin/collagen contents and to mechanical testing beyond rupture for the determination of failure properties and material characterization by the Fung-type model. RESULTS: Contrasting the direction-dependent (anisotropic) material constants and failure properties, and the primarily circumferential reinforcement of elastin/collagen fibers in healthy sinuses, near-similar (isotropic) properties and arbitrarily aligned fibers were found in the aneurysmal right and left coronary sinuses, together with less anisotropic properties in the aneurysmal noncoronary sinus. Variations between aneurysmal and healthy sinuses were comparable in young and old subjects. The former displayed significantly higher failure stress, failure stretch, and peak elastic modulus, justified by their increased elastin/collagen contents. CONCLUSIONS: We submit evidence of more isotropic histomechanical properties in the aneurysmal sinuses that seem consistent with the more axisymmetric stresses exerted on them owing to their more spherical shape, compared with the nondilated healthy sinuses that presented marked anisotropic properties.

Ibogaine related sudden death: a case report.

Ibogaine is a naturally occurring alkaloid derived from the roots of the rain forest shrub Tabernanthe iboga. Deaths have occurred temporarily related to the use of ibogaine. However, although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine for detoxification purposes. We report the case of a man who died suddenly 12-24 h after ibogaine use for alcohol detoxification treatment. In the autopsy liver cirrhosis and heavy fatty infiltration was found. The concentration of ibogaine was 2 mg/l. The potential risks of ibogaine use, especially for persons with pathological medical background, are discussed.

Current aspects of penal surgical liability in Greece.

The surgeon may face in every day practice issues that may render him liable. The legal liability usually emerges due to the negligence exhibited during the preoperative, the operative and the postoperative stage. The surgeon, as any doctor, isn't liable for the result, but he is responsible for the correct diagnosis and therapeutic treatment, always according to the principles of the Medical science and to the possibilities available to him in every specific case (facilities and time). The continuous education about the issues of his speciality, the adaptation of scientifically approved techniques, the correct monitoring of the patient, both preoperatively and postoperatively, and finally the good communication with the patient are necessary for the proper practice of Medicine; but also constitute the "shield" of the surgeon against any possible legal conflict.

Relationship between alcohol consumption and control of hypertension among elderly Greeks. The Nemea primary care study.

BACKGROUND: The aim of this study was to evaluate the significance of alcohol intake in relation to blood pressure control in treated subjects and to determine if there is a causative link between alcohol and inadequate control of hypertension. METHODS: Our study population comprised 637 elderly individuals who reside in Nemea and in four other villages located in Corinthia, Peloponnesus, of which 615 were included in the analysis. The average age was 73.5±6.15 years. A special epidemiological questionnaire was completed by each participant and the blood pressure (BP) was measured according to a predefined protocol. Odds ratios were calculated and adjusted for potential confounders. RESULTS: The overall prevalence of hypertension was 69.1%, 70.7% in men and 67.0% in women. In total, 11% of the hypertensives were not aware of having hypertension. Of those who were aware of having hypertension 91.0% were being treated. Among treated hypertensives 49.1% had systolic BP<140 mmHg and diastolic BP<90 mmHg. Only heavy drinking (>300 g/week) was found to be related with hypertension control. CONCLUSIONS: Our study showed that the level of control among the elderly, in a Greek population, is positively associated with alcohol intake only for heavy drinking. The role of alcohol consumption in hypertension in the elderly needs further investigation.

Biomechanical response of ascending thoracic aortic aneurysms: association with structural remodelling.

Ascending thoracic aortic aneurysms (ATAA) were resected from patients during graft replacement and non-aneurysmal vessels during autopsy. Tissues were histomechanically tested according to region and orientation, and the experimental recordings reduced with a Fung-type strain--energy function, affording faithful biomechanical characterisation of the vessel response. The material and rupture properties disclosed that ATAA and non-aneurysmal aorta were stiffer and stronger circumferentially, accounted by preferential collagen reinforcement. The deviation of microstructure in the right lateral region, with a longitudinal extracellular matrix and smooth muscle element sub-intimally, reflects the regional differences in material properties identified. ATAA had no effect on strength, but caused stiffening and extensibility reduction, corroborating our histological observation of deficient elastin but not collagen content. Our findings may serve as input data for the implementation of finite element models, to be used as improved surgical intervention criteria, and may further our understanding of the pathophysiology of ATAA and aortic dissection.

Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery disease.

BACKGROUND: The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD). METHODS: A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants. RESULTS: Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05). CONCLUSION: Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

Students' physical and psychological reactions to forensic dissection: Are there risk factors?

The reactions of students to forensic dissection encompass psychologico-emotional and physical components. This exploratory study aimed to determine risk factors for students' adverse physical and psychological reactions to forensic dissection. All sixth-year medical students (n = 304) attending the compulsory practical course in forensic medicine in the 2005-2006 academic year were asked to complete a questionnaire at the conclusion of the five-day course. The questionnaire surveyed physical and psychological reactions (outcomes) and 47 student traits, beliefs, and behaviors (risk factors) that might predispose to adverse reactions. Multivariate ordinal logistic regression yielded five independent risk factors for negative psychological reactions: female gender, stereotypic beliefs about forensic pathologists, a less cognitive and more emotional frame of mind relative to forensic dissection, more passive coping strategies, and greater fear of death. The sole independent risk factor for physical symptoms was a less cognitive/more emotional approach to dissection. Students' reactions to forensic dissection integrate a host of inherent and dissection-related risk factors, and future interventions to improve this aspect of medical education will need to take into account the complexities underlying students' experiences with dissection.

Smoking in prison: a hierarchical approach at the crossroad of personality and childhood events.

BACKGROUND: Smoking has long been considered part of prison culture and studies have shown a high prevalence of smoking within correctional facilities. METHODS: A self-administered, anonymous questionnaire was administered to 173 male prisoners in the Chalkida prison, Greece. To assess current smoking habits, a hierarchical approach was adopted. The underlying conceptual framework included: (i) demographic parameters, (ii) adverse childhood history (physical abuse, parental neglect, parental divorce, alcoholism in the family, sexual abuse and psychiatric condition in the family), (iii) education, personality traits, such as impulsivity (Barrat Impulsivity Scale-11), aggression (Buss-Perry Aggression Questionnaire and Lifetime History of Aggression), and personal history of mental disease, (iv) prison-related features (duration of sentence, sentence already served and change in smoking habits during imprisonment). RESULTS: Eighty percentage of the study sample reported current smoking; 43.4% disclosed deterioration in their smoking habits during imprisonment. The hierarchical approach pointed to: (i) adverse childhood events, i.e. alcoholism in the family [adjusted odds ratio (OR) = 6.29, 95% confidence interval (CI): 2.44-16.25], psychiatric condition in the family (adjusted OR = 4.10, 95% CI: 1.31-12.84), physical abuse (adjusted OR = 2.90, 95% CI: 1.30-6.46), parental neglect (adjusted OR = 2.66, 95% CI: 1.19-5.95), parental divorce (adjusted OR = 2.14, 95% CI: 1.00-4.56), and (ii) impulsivity (adjusted OR = 2.26, 95% CI: 1.12-4.58) as independent risk factors. In addition, deterioration of smoking habits during imprisonment exerted an effect of borderline significance (adjusted OR = 2.02, 95% CI: 0.97-4.24). CONCLUSIONS: Heavy smoking in prison principally integrates two components: unfavourable childhood and current personality traits (impulsivity).